Nattovena is specifically formulated to address fibrin imbalances in the body.
Fibrin is a protein that plays a major role in blood clotting and scar formation, making it an essential component of the healing process and vital for maintaining our health and general well-being. However, fibrin overproduction and impaired fibrin degradation has been implicated in many of today’s most common circulatory health concerns.
What is Nattokinase?
Nattokinase is a fibrinolytic (fibrin-dissolving) enzyme originally discovered within a Japanese fermented soybean food called natto. The dish consists of soybeans fermented with a strain of Bacillus subtilis bacteria that in turn produce the enzyme, which upon its discovery was later named after the respective dish. The fermented dish, natto, has a slimy texture, sour taste and strong smell that is very unappealing to some. Despite its questionable taste, natto has been shown in numerous studies to have many health benefits. For its use in nutritional supplements, the nattokinase enzyme is extracted and purified in a laboratory setting.
Nattovena provides twice the potency of ordinary nattokinase products available and is naturally acid stable in the stomach since it is derived from a food source. This gives Nattovena the added benefit of not having to use an enteric coating or plastic to protect it from stomach acid. Nattovena’s formula contains the highest Fibrinolytic Unit (FU) activity among the major brands of nattokinase supplements, allowing it to hydrolyze 4,000 units of fibrin per capsule, thereby optimizing its cardiovascular benefits and promoting normal blood viscosity.
How Does Nattokinase Work?
Fibrin is naturally produced in the body by a protein called thrombin and is degraded by the body's own fibrinolytic enzyme, plasmin. Fibrin is typically produced during the recovery and healing processes caused by injury or other health concerns. Usually, these processes exist in a delicate balance; however, many conditions can impair fibrin degradation and lead to excessive levels of fibrin within the body. Nattokinase supplementation can tip the balance back in favor of fibrin removal using two different mechanisms.
Firstly, nattokinase is a fibrinolytic enzyme, which means that it can literally dissolve excessive fibrin produced during the healing process. In fact, studies show that nattokinase is actually four times (4x) more potent than the body’s own plasmin in terms of fibrinolytic activity1. Secondly, nattokinase blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrinolytic capabilities even more. High levels of PAI-1 are directly linked to impaired fibrin degradation and removal, since PAI-1 blocks the body’s natural production of plasmin. By impeding PAI-1, nattokinase promotes the creation of more plasmin from plasminogen (its building block), increasing the amount of natural fibrinolytic enzymes created within the body2.
Clinical studies on nattokinase have demonstrated that nattokinase reduces the concentration of fibrinogen within the blood plasma of healthy adults. Examination of blood taken from patients supplementing oral nattokinase revealed the presence of the enzyme intact that was functionally capable of degrading fibrinogen, the building block of fibrin. Thereby nattokinase has been directly shown in a clinical setting to work throughout the body (the circulatory system) as opposed to within the confines of the digestive tract.
Directions: Take Nattovena with 8 oz of water on an empty stomach. Higher doses may be divided into 2 or 3 servings per day, but it is recommended to not exceed 9 capsules in any 24-hour period unless otherwise directed by a healthcare practitioner.*
Maintenance: 2 Capsules per day.*
Increased Support: 4 Capsules per day.*
Therapeutic: 6 Capsules per day.*
Warning: Do not take this product without the consent of your physician if you are currently taking blood thinning medications or if you are pregnant or nursing.